Nevertheless further work with additional samples and loci is needed to improve our initial assessment.
From a conservation perspective, we did not find a correspondence between genetic structure in lowland tapir and ecogeographic regions proposed to define conservation priorities in the Neotropics.
The authors stated that as a regulated secretory protein, BRCA1 appears to function by a mechanism not previously described for tumor suppressor products.
Climatic events at the end of the Pleistocene, parapatric speciation, divergence along the Andean foothill, and role of the Amazon river, have similarly shaped the history of other taxa.
BRCA1 plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability.
BRCA1 forms several distinct complexes through association with different adaptor proteins, and each complex forms in a mutually exclusive manner (19261749, images] [Full Text]" pmid="19261749"Miki et al.
(1994) identified c DNA sequences corresponding to the BRCA1 gene by positional cloning of the region on 17q21 implicated in familial breast-ovarian cancer syndrome (604370).
The deduced 1,863-residue protein with zinc-finger domains near the N terminus.
They noted that BRCA2 (600185) also includes a motif similar to the granin consensus at the C terminus of the protein.